The Link Between Opioid Use and Low Testosterone

Long-Term Opioid Use has Significant Effects on Testosterone

When you think of opioid addiction or long-term pain management, the focus is often on withdrawal symptoms, pain relief, and recovery. But there’s another consequence that rarely gets the attention it deserves: low testosterone. If you’ve been dealing with chronic pain or fighting your way through opioid addiction, low testosterone could be one of the silent, frustrating outcomes.

How Opioids Impact Testosterone Levels

Opioids are powerful painkillers that work by binding to specific receptors in the brain to block pain signals. They’re effective—often too effective—at dulling pain. But the problem is, they don’t just affect your pain receptors. They interfere with the hypothalamic-pituitary-gonadal (HPG) axis, the hormonal pathway responsible for testosterone production. When opioids disrupt this system, your body’s ability to produce testosterone takes a hit.

Why This Matters

Testosterone isn’t just about muscle or libido. It’s essential for your energy, mood, cognitive function, and even metabolism. When levels drop, you can feel sluggish, foggy-headed, weak, and frustrated by weight gain that seems to come out of nowhere. This is especially true if you’ve been using opioids for an extended period, whether to manage chronic pain or due to addiction.

Who’s Most at Risk?

  • Those Recovering from Opioid Addiction: If you’ve been through addiction, your testosterone levels may have been low for years before you even realized it. While recovery is a monumental achievement, the lingering effects of low testosterone can make the journey tougher than it has to be.

  • Long-Term Pain Patients: Maybe you had a major injury or surgery that required opioid painkillers. Months or even years of use can cause your testosterone levels to plummet without you even knowing it.

The Symptoms of Low Testosterone

How do you know if opioids have impacted your testosterone levels? Look out for signs like:

  • Fatigue that doesn’t go away, even after a full night’s sleep

  • Low libido and reduced sexual performance

  • Loss of muscle mass and strength

  • Increased body fat, particularly around the midsection

  • Mood swings, irritability, or even depression

  • Brain fog and trouble concentrating

What You Can Do About It

If you suspect opioids have damaged your testosterone levels, you don’t have to just live with it. Testing your hormone levels is a straightforward process. From there, treatments like testosterone replacement therapy (TRT) or lifestyle modifications can help restore your vitality and well-being.

The Bottom Line

Opioid addiction and chronic pain management shouldn’t come at the cost of your hormone health. Understanding the link between opioid use and low testosterone is the first step toward getting back to feeling like yourself again. And it’s absolutely possible.

If you’re ready to take control of your health and get your testosterone levels back where they should be, schedule a consultation today. The best version of you is waiting.


Let’s Connect


Dr. Pete Marta

I’m Dr. Peter Marta (affectionately known as Dr. Pete), a board-certified physician and surgeon. I focus on men’s health and hormone optimization. You don’t have to decline after 40. You can be in the best shape of your life from here on out.

Through my science-backed program, Codex, that combines the precision of conventional medicine, with the nuance of functional medicine, I’m here to help you reclaim your health and thrive after 40 and beyond.

https://www.petermarta.com/
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